Underweight Babies Linked to Gum Disease
Recent research by a medical team may show a link between periodontal
(gum) infection and the premature delivery of low birth weight (LBW) babies. The team consisted of Periodontist, obstetrician-gynecologists and epidemiologists.
The study, conducted at the University of North Carolina at Chapel Hill
and published in the October 1996 issue of the Journal of Periodontology,
found that women who had periodontal disease were seven times more likely
to have pre-term low birth weight babies (PLBW) than women who were not
affected by the disease. Untreated periodontal disease may be responsible
for a large percentage of PLBW in which other previously known risk factors
could not be identified.
Today in the United States, 10 percent of newborns are termed as being
low birth weight (less than five pounds, eight ounces) and these infants
account for five million neonatal intensive care unit days per year at
and annual cost of more than five billion dollars. Low birth weight
also has been related to 60 percent of infant deaths.
In addition, 25 percent of PLBW cases occur without the presence of known
risk factors such as smoking, genetics, alcohol use, level of prenatal
care, nutrition and urinary tract infection. Stephen Offenbacher, DDS,
Ph.D. , professor of the Periodontics, University of North Carolina school
of Dentistry and principal author of the study, points to previous studies
showing an association between infection and PLBW, specifically focusing
on genitourinary infections (GUI). It appears that these infections cause
an increased release of inflammatory chemicals which induce labor, thus
causing premature delivery before the fetus can grow to a normal birth
weight. Given that gum disease is also an infection, the researchers became
interested in whether the presence of infection in the gums could affect
the fetus or the premature onset of labor.
The research, conducted from 1991 to 1992, studied 124 women who were
pregnant or had recently delivered. While the study found a definite association
between gum disease and low birth weight babies, this does not necessarily
mean that these infections directly caused the premature onset of labor.
This study factored into its analysis a number of known to risk factors--
smoking, drug use, alcohol consumption, prenatal care, nutrition GUI,
and number of prior births--so that cases could be isolated where periodontal
disease was the defining variable in the outcome of the pregnancy.
Further research, which Dr. Offenbacher and his team are planning, will
be conducted using a larger population of pregnant women and will involve
studying pregnancies at multiple research centers.
"This study clearly shows that there is an association and that
periodontal disease in pregnant women may be a significant risk factor
for preterm low birth weight," said James T.Mellonig, DDS, MS, past
president of the American Academy of Periodontology. "We think that
pregnant women and their obstetricians need to be aware of these findings
and to be concerned about periodontal infection that can be detrimental
to the health of mother and baby. " If periodontal disease is diagnosed
and treated, the study estimates that PLBW may be reduced by 45,500 cases
annually.
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